A case of cutaneous phaeohyphomycosis caused by Phialophora verrucosa
10.3760/cma.j.issn.0412-4030.2011.11.019
- VernacularTitle:疣状瓶霉致暗色丝孢霉病一例
- Author:
Yonghao XU
;
Chunyang LI
;
Jie ZHAO
;
Keyu WANG
;
Shulan GUO
;
Ying SU
;
Jian JIAO
;
Qinfeng HU
- Publication Type:Journal Article
- From:
Chinese Journal of Dermatology
2011;44(11):809-811
- CountryChina
- Language:Chinese
-
Abstract:
A 16-year-old male presented with a 11-year history of progressively enlarging erythema and crusting on the right cheek.Physical examination revealed an irregularly shaped,sharply marginated,dark erythematous patch sized 6 cm x 10 cm and plaques with mild verrucous proliferation.There were strip-like scar at the margin of lesions and multiple ulcers measuring 0.5 to 1 cm in diameter with firm crusts.No small jellycolored nodules were observed.Direct microscopy of multiple scrapings under the crusts showed many light brown,septate,branching and irregular hyphae.Olivaceous-black woolly colonies grew at 25 C and 35 C on Sabouraud's dextrose agar and potato dextrose agar; flask-shaped conidiogenous cells with funnel-shaped collarettes and ellipsoidal conidia arranged in flower-like shape were observed microscopically.PAS staining showed numerous septate and branching hyphae,pseudohyphae and yeast-like cells.There was a 99.73％ similarity in the species-specific rDNA sequence between the isolate and phialophora verrucosa standard strain CDC-B2152.The patient was diagnosed with cutaneous phaeohyphomycosis caused by Phialophora verrucosa.The lesion subsided after treatment with amphotericin B and itraconazole,but recurred after drug withdrawal.Itraconazole and terbinafine were administered for the retreatment of this patient.
