Expressions of interferon regulatory factor 7 and Toll-like receptor 9 in peripheral blood mononuclear cells (PBMCs) of patients with condyloma acuminatum
10.3760/cma.j.issn.0412-4030.2011.11.018
- VernacularTitle:尖锐湿疣患者外周血单一核细胞中干扰素调节因子7和Toll样受体9mRNA的表达
- Author:
Yu LIU
;
Li WANG
;
Yuli WANG
- Publication Type:Journal Article
- From:
Chinese Journal of Dermatology
2011;44(11):807-808
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the role and clinical significance of interferon regulatory factor 7 (IRF7) and Toll-like receptor 9 (TLR9) in the development of condyloma acuminatum (CA).MethodsReverse transcription-PCR was performed to analyze the mRNA expressions of IRF7 and TLR9 in peripheral blood mononuclear cells(PBMCs) of 25 patients with CA and 20 normal human controls.ResultsThe expression levels of IRF7 and TLR9 mRNA in PBMCs were significantly higher in the patients with CA than in the controls(both P ＜ 0.01 ).Conclusion There is a significant increase in the expression of IRF7 and TLR9 in the PBMCs of patients with CA.
