Influences of routine-dose loratadine on the intensity of patch test reaction

VernacularTitle:常规剂量氯雷他定对皮肤斑贴试验反应程度的影响
Author: Ping LI ; Xiaodong SUN ; Xin SHI ; Yonglian CAI ; Jing ZHANG ; Xiaojian CHEN ; Lingling CHEN ; Lixia XIE
Publication Type:Journal Article
Keywords: Nickel; Skin irritancy tests; Loratadine
From: Chinese Journal of Dermatology 2011;44(11):765-767
CountryChina
Language:Chinese
Abstract: ObjectiveTo investigate the influences of routine-dose loratadine on the positive patch test reaction to nickel sulfate.MethodsA double-blind,controlled and randomized study was carried out.A total of 121 patients with a positive patch test reaction to nickel sulfate were divided into two groups to receive loratadine 10 mg (experimental group,n =61 ) or placebo (control group,n =60) once daily for 14 days.The patch testing of nickel sulfate was performed on day 11,and clinical evaluation of the test was carried out on day 14 after the start of treatment.The intention to treat population was used for data analysis.ResultsNo changes were observed in the intensity of patch test reaction to nickel sulfate in 55 patients in the experimental group or 53 patients in the control group,and there was no significant difference between the two groups in the percentage of patients showing changes in the intensity of patch test reaction(9.8％ vs.11.7％,x2 =0.11,P ＞ 0.05).ConclusionThe routine-dose loratadine has no inhibitory effect on the intensity of skin patch test reaction to nickel sulfate.