A study on the cerebral glucose metabolism in progressive supranuclear palsy
10.3760/cma.j.issn.0578-1426.2012.11.013
- VernacularTitle:进行性核上性麻痹的脑葡萄糖代谢研究
- Author:
Aijun MA
;
Xiaojun GUO
;
Dacheng LI
;
Benshu ZHANG
;
Xudong PAN
- Publication Type:Journal Article
- Keywords:
Possitror-Emission tomography;
Parkinson disease;
Progressive supranuclear palsy
- From:
Chinese Journal of Internal Medicine
2012;51(11):885-888
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the regional cerebral glucose utilization with 18 F-fluorodeoxyglucose (FDG) PET and to investigate the correlation between cerebral glucose metabolism and the clinical characteristic of progressive supranuclear palsy (PSP).Methods A total of 13 patients with PSP and 30 matched healthy controls were performed 18F-FDG PET imaging at rest state.Visual inspection and statistical parametric mapping (SPM) were used to investigate regional cerebral metabolic rate of glucose (rCMRglc).Results Based on the visual inspection,PET imaging in the PSP patients showed that the focal hypometabolic areas mainly included the bilateral frontal cortex,midbrain and subcortical structures.Compared to the controls,voxel-based analysis showed that the regional glucose metabolism decreased in bilateral superior,middle frontal gyrus,cingulate gyrus,midbrain and subcortical structures including basal ganglion and thalamus,which were consisted with the clinical characteristics,such as vertical gaze palsy,pseudobulbar palsy,postural instability,axial rigidity,dementia and so on.Conclusion 18 F-FDG PET imaging is helpful for the early diagnosis of PSP.
