The value of serum intestinal fatty acid binding protein measurement in discriminating intestinal ischemia in patients with acute abdomen
10.3760/cma.j.issn.0578-1426.2012.09.010
- VernacularTitle:肠脂肪酸结合蛋白在急腹症患者中鉴别急性肠缺血的价值
- Author:
Hui SHI
;
Benyan WU
;
Wenhui LIU
;
Binbin SU
;
Tingting LI
- Publication Type:Journal Article
- Keywords:
Abdomen,acute;
Diagnosis,differential;
Intestinal ischemia;
Intestinal fatty acid binding protein
- From:
Chinese Journal of Internal Medicine
2012;51(9):690-693
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo assess the differential diagnostic value of serum intestinal fatty acid binding protein (I-FABP)in distinguishing intestinal ischemia patients from acute abdomen patients.MethodsA total of 151 patients with acute abdomen and 17 healthy controls from the PLA General Hospital were enrolled from November,2009 to August,2011. Serum I-FABP levels were measured by ELISA.According to the ROC curve,the cut-off value,sensitivity,specificity,positive likelihood ratio (PLR),negative likelihood ratio ( NLR),positive predietive value (PPV) and negative predictive value (NPV) were calculated. ResultsOf the 151 acute abdomen patients,there were 24 intestinal ischemia patients and 127 without intestinal ischemia.Serum I-FABP level in intestinal ischemia group [( 109.67 ±48.82) μg/L]was significantly higher than those in patients without intestinal ischemia [(36.78 ± 11.25) μg/L]and healthy controls[(8.33 ±6.25) μg/L]( all P values ＜0.01 ).The serum I-FABP cut-off value for the diagnosis of intestinal ischemia was 87.52 μg/L.Serum I-FABP was efficient in terms of sensitivity (0.762),NPV(0.963),PLR(3.05) and NLR (0.24) in the diagnosis of intestinal ischemia.ConclusionI-FABP is potentially useful for discriminating intestinal ischemia from acute abdomen.
