Recent progress in studies on metabolism and pharmacogenomics of sulfonylurea agents
10.3760/cma.j.issn.1000-6699.2012.10.021
- VernacularTitle:磺脲类药物代谢及其药物基因组学研究进展
- Author:
Qing LI
;
Cheng HU
;
Weiping JIA
- Publication Type:Journal Article
- Keywords:
Sulfonylureas agents;
Gene;
Pharmacogenomics;
Diabetes mellitus,type 2
- From:
Chinese Journal of Endocrinology and Metabolism
2012;28(10):866-868
- CountryChina
- Language:Chinese
-
Abstract:
The sulfonylureas as insulin secretagogues,have formed a cornerstone of pharmacotherapy for type 2 diabetes over 50 years.Although sulfonylureas are effective antihyperglycemic agents,individual variability exists in drug response (i.e.,pharmacodynamics) and adverse effects which may be related to some genes.This article mainly reviews the advance of recent studies about drug metabolism and pharmacogenomics of sulfonylureas.
