Comparative performance of the equations for estimating GFR in type 2 diabetic patients
10.3760/cma.j.issn.1000-6699.2012.10.013
- VernacularTitle:不同肾小球滤过率评估方程在2型糖尿病患者中的适用性
- Author:
Hongxia GU
;
Li QIN
;
Qun SHI
;
Qing SU
- Publication Type:Journal Article
- Keywords:
Diabetic nephropathies;
MDRD equation;
Cockcroft-Gault formula;
CKD-EPI equation
- From:
Chinese Journal of Endocrinology and Metabolism
2012;28(10):839-842
- CountryChina
- Language:Chinese
-
Abstract:
Serum creatinine was determined by enzymatic method.99mTc-GFR was measured by 99mTc-DTPA dynamic renal imaging and considered as GFR marker in 210 males and 180 females with type 2 diabetes,eGFR was calculated by Cockcroft-Gault formula,MDRD equation7,abbreviated MDRD equation,modified MDRD equation for Chinese (c-7GFR4 and c-aGFR4),and CKD-EPI equation.They were analyzed by correlation,regression,Bland-Altman analysis and receiver operating characteristic (ROC) curve analysis.The correlation coefficients for Cockcroft-Gault formula,MDRD equation7,abbreviated MDRD equation,c-7GFR4,c-aGFR4,and CKD-EPI equation were 0.79,0.76,0.77,0.76,0.76,0.81 respectively.And the differences were-14.99,-18.85,-23.79,-25.85,-32.07,and-7.16,respectively.The area under ROC curves were 0.91,0.88,0.89,0.88,0.90,and 0.92,respeetively.Kappa values were 0.67、0.52、0.39、0.49、0.46、0.54respectively.The CKD-EPI equation seams to be the most accurate measurement among the six methods when the serum creatinine was determined by enzymatic method in Chinese type 2 diabetic patients.
