Risk factors for early postoperative cognitive dysfunction in elderly patients undergoing spinal surgery
10.3760/cma.j.issn.0254-1416.2012.08.010
- VernacularTitle:老年脊柱手术患者术后早期认知功能障碍的危险因素
- Author:
Xueqiang PENG
;
Zhiqun LIU
;
Lun WU
;
Fubin OU
;
Hongtao LIANG
;
Xiaoxin ZHANG
;
Zhiheng XIAO
;
Xiaobing ZHU
- Publication Type:Journal Article
- Keywords:
Aged;
Surgical procedures,operative;
Cognition;
Spine;
Risk factors
- From:
Chinese Journal of Anesthesiology
2012;32(8):939-941
- CountryChina
- Language:Chinese
-
Abstract:
Objective To identify the risk factors for early postoperative cognitive dysfunction (POCD) in the elderly patients undergoing spinal surgery.Methods One hundred and fifty ASA Ⅱ or Ⅲ patients,aged ≥65 yr,undergoing elective spinal surgery under general anesthesia,were studied.Venous blood samples were taken at 1 day before operation and 7 days after operation to determine the concentration of serum S-100B protein.Cognitive function was assessed by Mini-Mental State Examination (MMSE) at 1 day before operation and 7 days after operation.The patients were diagnosed as having POCD if MMSEpre-MMSEpost ≥ 3.The patients were divided into POCD group and non-POCD group.Age,body weight,sex,education,type of operations,complications,preoperative TCM syndrome type,MMSE score at 1 day before operation and 7 days after operation,duration of operation,emergence time,and intraoperative blood loss,cardiovascular events,and amount of fluid infused per hour were recorded.The risk factors for POCD were analyzed using multivariate logistic regression analysis.Results Thirty-eight patients developed early POCD (25.3％).The resuhs of logistic regression analysis showed that age ≥ 70 yr,elementary education or below,duration of operation ≥5 b,and the number of hypotension occurred during operation≥3 were the risk factors for early POCD.Conclusion Age≥70 yr,elementary education or below,duration of operation ≥ 5 h,and the number of hypotension occurred during operation ≥ 3 are the risk factors for early POCD in the elderly patients undergoing spinal surgery.
