Clinicopathological characteristics of non-muscle-invasive bladder cancer patients association with chronic kidney disease
10.3760/cma.j.issn.1000-6702.2012.02.007
- VernacularTitle:慢性肾病对非肌层浸润性膀胱癌临床病理特点的影响
- Author:
Kui ZHANG
;
Wei YU
;
Xinyu YANG
;
Qun HE
;
Yi SONG
;
Jie JIN
- Publication Type:Journal Article
- Keywords:
Urologic neoplasms;
Carcinoma,transitional cell;
Urinary bladder neoplasms;
Renal insufficiency,chronic;
Risk assessment
- From:
Chinese Journal of Urology
2012;33(2):104-106
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinicopathological characteristics of non-muscle-invasive bladder cancer patients association with chronic kidney disease (CKD).Methods Between Jan 2009 and Dec 2010,536 patients (390 males and 146 females with mean age of 63 years) underwent surgical treatment at our institute for pathologically proven non-muscle-invasive bladder cancer.The clinical and pathological data of these patients were reviewed,and the relationships of these factors and CKD were analyzed.Presence of CKD was confirmed in patients with estimated glomerular filtration rate (eGFR)＜ 60ml/(min · 1.73 m2)calculated using the Modification of Diet in Renal Disease Study equation.Results Of the 536 consecutive cases,57 patients (10.6％) had CKD.Compared to the patients without CKD,there were more females and older patients in the patients with CKD (52.6％ vs 24.2％ and 69 years vs 62 years,both P ＜ 0.05).The patients with CKD proned to have multiple bladder tumor (71.9％ vs 50.9％,P ＜ 0.05) and synchronous upper urinary tract urothelial carcinoma (7.0％ vs 2.3％,P ＜0.05).The history of bladder cancer and upper urinary tract urothelial carcinoma were also predominated in these patients (43.9％ vs 29.0％ and 40.4％ vs 6.5％,both P ＜ 0.05).ConclusionConcurrent CKD in non-muscle-invasive bladder cancer patients is associated with greater risk of multiple tumors in urinary tract,particularly in female patients.
