Effects of aged and exercise on hydroxylysylpyridinoline crosslinking concentrations of left ventricule in rats
10.3760/cma.j.issn.0254-9026.2012.11.028
- VernacularTitle:增龄与运动对大鼠左心室羟基赖氨酰吡啶啉交联水平的影响
- Author:
Xia LI
;
Youdong HU
;
Yan GUO
- Publication Type:Journal Article
- Keywords:
Aged factors;
Exercise test;
Extracellular matrix
- From:
Chinese Journal of Geriatrics
2012;31(11):1019-1021
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of aged and exercise training on hydroxylysylpyridinoline (HP) crosslinking concentrations of extracellular matrix in right ventricular (RV),left ventricular septum (LVS) and left ventricular free-wall (LVFW) in Fischer 344 rats.Methods We evaluated HP crosslinking concentrations of RV,LVS and LVFW extracellular matrix in young adult versus old Fischer 344 rats using high-pressure liquid chromatography (HPLC).Rats were assigned to either a sedentary control group or an exercise training group.Results HP crosslinking concentrations in LVS [(0.23±0.01) vs.(0.43±0.03)mol HP/mol Col,P＜0.05] and LVFW [(0.22±0.05) vs.(0.51±0.03) mol HP/mol Col,P＜0.05] in old sedentary control rats were elevated compared with adult sedentary rats.In adult exercise training rats,training had no effect on HP crosslinking concentration in any of the three regions of the heart.As compared with old sedentary rats,HP crosslinking concentrations in LVS [(0.22±0.06) mol HP/mol Col vs.(0.43±0.03)mol HP/mol Col,P＜0.05] and LVFW[(0.21±0.07)mol HP/mol Col vs.(0.51±0.03) mol HP/mol Col,P＜0.05] were decreased in old exercise training rats.Conclusions HP crosslinking concentration are increased with aging in LVS and LVFW of rats,and exercise can prevente this age associated change.
