Association between gene polymorphism of plasminogen activator inhibitor and ischemic cerebrovascular disease in aged people of Henan Han nationality
10.3760/cma.j.issn.0254-9026.2012.11.021
- VernacularTitle:河南汉族老年患者纤溶酶原激活抑制物基因多态性与缺血性脑血管病的关系
- Author:
Ning ZHANG
;
Zhenhua WANG
;
Yujun CHEN
;
Xiahong WANG
;
Yuming XU
- Publication Type:Journal Article
- Keywords:
Ischemic encephalopathy;
Plasminogen activator inhibitor-1;
Polymorphism,single nucleotide;
Han nationality
- From:
Chinese Journal of Geriatrics
2012;31(11):994-997
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association between gene polymorphism of plasminogen activator inhibitor (PAI-1)and ischemic cerebrovascular disease in aged people of Henan Han nationality.Methods A case control method was used,including 408 patients with ischemic cerebrovascular disease and 418 age and gender matched healthy controls.Polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) method was used to determine the distribution of allele and genotype frequencies of PAI-1 844G/A.Results In patient group,the gene frequencies of AA,AG,GG were 18.1％,41.4％,40.4％,and the A and G allele frequencies were 38.8％ and 61.2％,respectively.In the control group,the gene frequencies of AA,AG,GG were 15.8％,47.4％,36.8％,and the A and G allele frequencies were 39.5％ and 60.5％.There were no significant differences in the frequencies of genotypes and alleles between the two groups (P＞0.05).The different genotypes of 844G/A of PAI-1 gene were not associated with hypertension,hyperglycemia,plasma homocysteic acid levels (P ＞ 0.05).Conclusions PAI-1 gene-844G/A polymorphism may not be independent risk factor of ischemic cerebrovascular disease in aged people of Henan Han nationality.
