Value of stroke volume variation in guiding fluid resuscitation therapy in the elderly septic patients
10.3760/cma.j.issn.0254-9026.2012.11.013
- VernacularTitle:每搏输出量变异指数在老年脓毒症患者液体复苏中的价值
- Author:
Jin CHEN
;
Jing YAN
;
Shijin GONG
;
Guolong CAI
;
Haiwen DAI
;
Yihua YU
;
Qianghong XU
;
Molei YAN
;
Chengwu TAN
;
Liang WU
- Publication Type:Journal Article
- Keywords:
Sepsis;
Resuscitation;
Stroke volume
- From:
Chinese Journal of Geriatrics
2012;31(11):967-970
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical values of central venous pressure (CVP) versus stroke volume variation (SVV) in patients with severe sepsis after early goal-directed therapy (EGDT).Methods Totally 30 mechanically ventilated patients with severe sepsis who underwent goal-achieved EGDT were enrolled and randomly divided into CVP group (study group) and SVV group (control group) according to the data detected by pulse contour continuous cardiac output (PiCCO) analysis device.The differences in 28-day survival,3-day APACHE Ⅱ score,time of ICU stay,duration of mechanical ventilation,number that need CRRT,entral venous pressure (CVP),heart end-diastolic volume index (GEDVI),intrathoracic blood volume index (ITBVI),extravascular lung water index (EVLWI),cardiac index (CI),central venous oxygen saturation (ScvO2),lactate clearance rate and APACHE Ⅱ score were compared between the 2 groups.Results The death rate had no difference between the 2 groups(x2=0.240,P=0.624).Among survival patients in the CVP group,the time of ICU stay and duration of mechanical ventilation were shorter in study group than in control group(t=2.166,P=0.041;t=2.104,P=0.046),APACHE Ⅱ score at 3th day was decreased(t=2.20,P =0.038).The values of ITBVI,GEDVI,CI,lactate clearance rate were higher in study group than in control group (t=2.759,2.146,2.199,2.654,3.362,P=0.011,0.043,0.038,0.014,0.003).EVLWI and APACHE Ⅱ score were not different (P＞0.05) between the two groups.Conclusions SVV as a recovery target for fluid resuscitation can reach a better recovery results and improvement of prognosis than CVP goal-achieved EGDT.
