Adverse thrombogenic events induced by discontinuing aspirin in patients during prostate operation: case report and review
10.3760/cma.j.issn.0254-9026.2012.11.005
- VernacularTitle:前列腺切除或活检围术期停用阿司匹林致心脑血管事件分析并文献复习
- Author:
Lei SU
;
Fang WU
;
Wen HE
- Publication Type:Journal Article
- Keywords:
Prostatic hyperplasia;
Aspirin;
Stroke;
Myocardial infarction
- From:
Chinese Journal of Geriatrics
2012;31(11):941-942
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the incidence of thrombogenic events during the prostate operation period in patients discontinuing aspirin.Methods Among a retrospective cohort of 342 patients admitted in our institution for benign prostatic hyperplasia (or prostate cancer),combined with acute coronary syndrome (or stroke),we studied 4 patients who had not been taking aspirin before thrombogenic vascular event.Data on age,sex,vascular disease risk factors,and clinical outcome were collected.Results The 4 patients' mean age was 78.8±5.9 years.Each patient had at least two following risk factors:atrial fibrillation,old cerebral infarction and type 2 diabetes.80％ patients had a clinical history of hypertension.2 of the 4 patients stopped aspirin before a surgical procedure and developed acute ischemic stroke and acute myocardial infarction,separately.The other two patients developed acute ischemic stroke without aspirin prescription.The median time between admission and thrombogenic events was 15.5± 10.5 days.All patients were not given finasteride on admission.Conclusions This study should alert clinicians to know the risk of aspirin withdrawl perioperatively in patients at high risk of cardiovascular and cerebrovascular diseases.
