Effect of finasteride on perioperative bleeding following transurethral plasmakinetic resection of prostate
10.3760/cma.j.issn.0254-9026.2012.11.008
- VernacularTitle:经尿道前列腺等离子切除术中非那雄胺减少出血的疗效观察
- Author:
Wengong SUN
;
Jie ZHANG
;
Dehai LIU
;
Qingze MENG
;
Peng LI
- Publication Type:Journal Article
- Keywords:
Prostatic hyperplasia;
Transurethral resection of prostate;
Finasteride;
Intraoperative complications
- From:
Chinese Journal of Geriatrics
2012;31(11):949-951
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of finasteride on perioperative bleeding following transurethral plasmakinetic resection of prostate (PKRP).Methods A total of 118 patients with benign prostatic hyperplasia (BPH) undergoing PKRP were randomly divided into three groups:40cases received 5mg of finasteride daily for 7 days before surgery as 1 week group,38 cases received 5mg of finasteride daily for 3 months before surgery as 3 months group,the other 40 cases without taking finasteride before surgery as control group.A comparative study of clinical data was made among the three groups.Results The operation was successfully completed in 118 cases.As compared to control group,intraoperative irrigating fluid volume[(31.5 ± 5.6) L vs.(26.4 ± 6.2) L and (24.3±5.2)L],intraoperative blood loss[(173.5± 16.9) ml vs.(163.5± 15.8) ml and (156.4±16.2) ml],loss of 1 gram prostate tissue for resection[(8.6±4.8)ml/g vs.(7.4±5.4) ml/g and (6.6±5.6) ml/g]and operation time(72.5±16.2) min vs.(58.4±17.8) min and (56.7±16.5) min in 1 week and 3 months groups with taking finasteride were decreased (all P＜0.05).And there were differences in the above indexes (all P＜ 0.05) between 1 week group and 3 months groups.Conclusions The use of finasteride before PKRP is safe and reliable to reduce perioperative bleeding in BPH patients.Moreover,taking 5mg of finasteride for three months is of better effectiveness than taking 5mg of finasteride for 1 week.
