Effect of combined anti-platelets drugs on platelet activation in the elderly patients with acute coronary syndrome
10.3760/cma.j.issn.0254-9026.2012.10.006
- VernacularTitle:联合应用抗血小板药物对老年急性冠状动脉综合征患者血小板活化功能的影响
- Author:
Dahai HUANG
;
Haimei QI
- Publication Type:Journal Article
- Keywords:
Platelet activation;
Acute coronary syndrome;
Platelet glycoprotein GP Ⅱ b-Ⅲ a complex
- From:
Chinese Journal of Geriatrics
2012;31(10):850-853
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of combined anti-platelets drugs on platelet activation in the elderly patients with acute coronary syndrome (ACS).Methods Totally 72 elderly patients with ACS were divided randomly into two groups according to age ≤ 80 years and ＞ 80 years.Aspirin 100 mg/d plus clopidogrel 75 mg/d were used in all the patients for 2 weeks.The positive glycoprotein Ⅱb/Ⅲa and P-selectin expressions on the surface of platelets were assessed with flow cytometry (FCM) after the platelets were activated by adenosine diphosphate (ADP) and arachidonic acid.Results The expressions of GP Ⅱb/Ⅲa and P-selectin were (73.5± 11.0,71.2±8.7) ％ at baseline and (51.3±9.1,57.3±12.4)％ after anti-platelets medicine more than 14 days in group of age≤80 years.than 14 days.The expression of GP Ⅱb/Ⅲa and P-selectin were (78.3 ±12.7,75.8±8.6)％ on the surface of platelet at baseline in group of age＞ 80 years,after anti-platelets medicine treatment were (41.2±8.5,47.3±10.3)％.The positive expressions of GP Ⅱb/Ⅲa and P-selectin in group of age＞ 80 years were decreased compared with those in group of age≤ 80 years after combination of medicines treatment (P＜0.05).Conclusions Combined aspirin and Clopidogrel treatment have a more strong effect in inhibiting the activation of platelets in the elderly patients more than 80-year with ACS.
