Surgical treatment of giant cell tumor of bone around the knee: a multicenter retrospective study
10.3760/cma.j.issn.0253-2352.2012.11.010
- VernacularTitle:膝关节周围骨巨细胞瘤治疗的多中心回顾性研究
- Author:
Han WANG
;
Yongcheng HU
;
Xiuchun YU
;
Zhen WANG
;
Sujia WU
;
Zhaoming YE
;
Ningjun WAN
;
Ming XU
;
Haodong ZHU
;
Nong LIN
;
Bo HU
;
Binbin YUAN
- Publication Type:Journal Article
- Keywords:
Knee joint;
Giant cell tumor of bone;
Prognosis;
Multicenter studies
- From:
Chinese Journal of Orthopaedics
2012;32(11):1040-1047
- CountryChina
- Language:Chinese
-
Abstract:
Objective To retrospectively analyze treatment status quo of giant cell tumor of bone around the knee in several institutes,and to investigate risk factors affecting selection of surgical manners,tumor recurrence,and functional outcomes.Methods A total of 222 patients with giant cell tumor of bone around the knee confirmed by pathology,who had undergone surgical treatment in 5 institutes from March 2000 to May 2012,were enrolled in this study.There were 120 males and 102 females,with an average age of 35.5 years.The epidemiology,clinical and radiographic features and risk factors affecting selection of surgical manners,tumor recurrence,and functional outcomes were analyzed.Results Intralesional curettage was performed in 128 patients(57.6％),intralesional curettage combined with partial resection in 13 patients (5.8％),and marginal excision in 79 patients (35.5％).A total of 159 patients were followed up.The local recurrence rate was 19.0％ for patients treated with intralesional curettage,8.9％ for marginal excision and 0％ for intralesional curettage combined with partial resection,and the total local recurrence rate was 14.5％(23/159).The mean duration from primary operation to recurrence was 23.9 months.Univariate analysis indicated that surgical manner was the only factor affecting local recurrence.Pathological fracture,Campanacci grades,Enneking system as well as soft tissue mass had a significant influence on the selection of surgical manners.The mean MSTS score after intralesional curettage was obviously higher than that after marginal excision.Conclusion The surgical manner is the only factor affecting local recurrence and limb function.
