Anti-thrombopoietin antibodies in systemic lupus erythematosus with thrombocytopenia

Xiaodan WU; Xiongyan LUO; Long CHEN; Jing ZHANG; Tong WU; Minghui YANG; Bin ZHOU

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Anti-thrombopoietin antibodies in systemic lupus erythematosus with thrombocytopenia

VernacularTitle:抗血小板生成素抗体与系统性红斑狼疮伴血小板减少的相关性研究
Author: Xiaodan WU ; Xiongyan LUO ; Long CHEN ; Jing ZHANG ; Tong WU ; Minghui YANG ; Bin ZHOU
Publication Type:Journal Article
Keywords: Lupus erythematosus,systemic; Thrombocytopenia; Anti-thrombopoietin antibodies
From: Chinese Journal of Rheumatology 2012;16(11):745-748
CountryChina
Language:Chinese
Abstract: Objective To investigate the existence and significance of circulating autoantibodies to thrombopoietin (TPO) in sera from patients with systemic lupus erythematosus (SLE).Methods Fifty-six consecutive patients with SLE,twenty patients with idiopathic thrombocytopenic purpura (ITP),and twenty normal individuals were involved in this study.The characteristics of all patients with SLE were analyzed.Antibodies to TPO were detected using an enzyme-linked immunosorbent assay (ELISA).For normal distribution count data,x2 test or Fisher exact test was used,t test was used for measurement data,and Wilcoxon's rank test for non-normally distributed data which was represented by M(Q).Results A higher frequency of antibodies to TPO were observed in SLE patients than those in healthy controls (39.3％ vs 0,x2=11.058,P=0.001).Moreover,anti-TPO antibodies were detected in 15 (57.7％) of 26 SLE patients with thrombocytopenia,compared with that in 7 (23.3％,x2=6.894,P=0.009) of 30 patients without thrombocytopenia.Furthermore,the patients with antibodies to TPO exhibited more severe thrombocytopenia (t=3.010,P=0.004).Finally,anti-TPO antibodies seemed more likely to occur in patients with arthritis (x2=5.959,P=0.015),anti-dsDNA antibodies (x2=5.959,P=0.015).Conclusion The high incidence of antibodies to TPO in SLE patients with thrombocytopenia suggests that anti-TPO antibodies might play a vital role in SLE patients developing thrombocytopenia.Thus,there might be a clinical value by detecting anti-TPO antibodies in SLE patients with thrombocytopenia.