The level and clinical significance of interleukin-17 in primary Sj(o)gren's syndrome with interstitial lung disease
10.3760/cma.j.issn.1007-7480.2012.11.005
- VernacularTitle:原发性干燥综合征伴肺间质损害患者血清中白细胞介素-17水平及其临床意义的研究
- Author:
Yitian SHI
;
Xianghui MENG
;
Tingting SUN
;
Bailing TIAN
;
Shan ZHAO
;
Pingting YANG
;
Weiguo XIAO
- Publication Type:Journal Article
- Keywords:
Sj(o)gren's syndrome;
Lung disease,interstitial;
Interleukin-17
- From:
Chinese Journal of Rheumatology
2012;16(11):738-740
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the level of IL-17 and its clinical significance in patients with primary Sj(o)gren's syndrome (pSS) complicated with interstitial lung disease (ILD).Methods IL-17 levels were detected by enzyme linked immunosorbent assay (ELISA) in 53 untreated patients with pSS (25patients with only lacriminal and/or salivary gland involvement,28 with only interstitial lung disease involvement) and 15 healthy controls.The related clinical and laboratory data were recorded.ANOVA,LSDtest and Pearson test were used for statistical analysis.Results There were significant differences between the 3 groups(F=22.504,P=0.000).The mean concentration of sera IL-I7 in the patients with ILD was significantly higher than in patients with only lacriminal or salivary gland involvement (P＜0.05).There was no difference in the levels of sera IL-17 between the patients with only lacriminal and/or salivary gland involvement and healthy controls (P＞0.05).Conclusion Our results show that patients with pSS concomitant with ILD have high serum IL-17 levels,which highlight the role of IL-17 in Sj(o)gren's syndrome interstitial lung injury.
