Establishment and evaluation of classification criteria for early rheumatoid arthritis
10.3760/cma.j.issn.1007-7480.2012.10.002
- VernacularTitle:早期类风湿关节炎分类标准及其诊断意义的探讨
- Author:
Jinxia ZHAO
;
Yin SU
;
Xiangyuan LIU
;
Hua YE
;
Ru LI
;
Qinghua ZOU
;
Yongfei FANG
;
Huaxiang LIU
;
Xingfu LI
;
Jialong GUO
;
Liqi BI
;
Fei GU
;
Lingyun SUN
;
Yifang MEI
;
Zhiyi ZHANG
;
Lina CHEN
;
Ping ZHU
;
Guangtao LI
;
Zhuoli ZHANG
;
Xiaomei LENG
;
Yan ZHAO
;
Li JIANG
;
Hejian ZOU
;
Yi ZHAO
;
Yi LIU
;
Lei LI
;
Hongyuan WANG
;
Zhanguo LI
- Publication Type:Journal Article
- Keywords:
Arthritis,rheumatoid;
Early diagnosis;
Classification criteria
- From:
Chinese Journal of Rheumatology
2012;16(10):651-656
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish new classification criteria for early rheumatoid arthritis (E-RA) based on large samples of early inflammatory arthritis patients and to evaluate the value of this criteria in China.Methods Patients who had arthritic complaints with disease duration less than one year were enrolled.They were divided into RA group and non-RA group according to the clinical diagnosis by experienced rheumatologists.The clinical and laboratory parameters were analyzed and those with high sensitivity or specificity were selected as the new classification criteria.Statistical analysis was carried out by using t test,x2 test and Logistic regression.Results ① A total of 803 patients with early inflammatory arthritis were included in this study.Five hundreds and fourteen patients were diagnosed as early RA and 251 were diagnosed as other rheumatic diseases,and the diagnosis of 38 patients remained unestablished by the end of follow-up.② New E-RA classification criteria were established based on the parameters with high sensitivity and/or specificity.The sensitivity of the new E-RA criteria was 84.4％,which was higher than 1987 ACR criteria (58.0％),while the corresponding specificities were similar,which were 87.4％ and 93.6％ respectively.③ Compared with the complex scoring system of 2010 ACR/EULAR criteria,the E-RA criteria was more simple and practical.The diagnostic sensitivity and specificity of E-RA criteria were higher than those of 2010 ACR/EULAR criteria reported in the literatures.④ New classification criteria based on scoring system using Logistic regression analysis was established.The sensitivity of this criteria was 86.4％,which was higher than 1987 ACR criteria (58.0％).Conclusion The diagnostic value of the E-RA criteria developed in this study for early RA is better than 1987 ACR criteria,and is more simple than 2010 ACR/EULAR criteria.It may be used as a new classification criteria for early RA diagnosis.
