Tumor necrosis factor like ligand-1A in rheumatoid arthritis patient and its clinical relevance analysis
10.3760/cma.j.issn.1007-7480.2011.09.007
- VernacularTitle:类风湿关节炎患者血清中肿瘤坏死因子样配体1A的测定及临床意义
- Author:
Jing ZHAO
;
Xiaolin SUN
;
Rulin JIA
;
Lihong CHEN
;
Xia LI
;
Lingyun SUN
;
Zhanguo LI
- Publication Type:Journal Article
- Keywords:
Arthritis,rheumatoid;
Rheumatoid factor;
Tumor necrosis factor like ligand-lA;
Anti-cyclic citrullinated peptide antibody
- From:
Chinese Journal of Rheumatology
2011;15(9):608-610
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo analyze the correlated clinical significance by testing the serum tumor necrosis factor like ligand-1A(TL1A) levels of patients with rheumatoid arthritis(RA). MethodsThe serum from 100 RA patients and 50 healthy controls were selected. The serum TL1A concentrations of the two groups were detected by ELISA. The correlations between serum TL1A levels and clinical features or laboratory examinations of RA patients were investigated. Mann-Whitney U test, t-test, x2 test and Spearman correlation analysis were used for statistical analysis. ResultsThe levels of serum TL1A in RA patients [(959±1146) pg/ml]were significantly higher than those of the healthy controls[(529±154) pg/ml, t=3.683,P＜0.01]. The levels of serum TL1A in RA patients with positive rheumatoid factor(RF),occult rheumatoid factor immunoglobulin G (HRF-IgG) and anti-cyclic citrullinated peptide antibodies (anti-CCP)[(962±1043 ), ( 833±1104 ), (908±1115 ) pg/ml, respectively]were significantly increased when compared to those in RF, HRF-IgG and anti-CCP negative RA patients[(628±r343), (576±134),(628±401) pg/ml, respectively, t=3.224, 1.317, 1.003; P＜0.05]. The positive rates of RF, HRF-IgG and anti-CCP in the TL1A positive group(90％, 42％, 85％) were significantly higher than those of the TL1A negative group (56％, 11％,33％) (x2=-0.372, -2.402, -2.774; P＜0.05). ConclusionThe level of serum TL1A is significantly elevated in RA and it is significantly associated with auto-antibodies in RA including RF, HRF-lgG and antiCCP antibody, which may be a factor for unfavorable prognosis of RA patients.
