Meta-analysis of predictive factors of interstitial lung disease in patients with polymyositis and dermatomyositis
10.3760/cma.j.issn.1007-7480.2011.09.002
- VernacularTitle:多发性肌炎/皮肌炎合并间质性肺疾病预测因素的Meta分析
- Author:
Fang CHEN
;
Guochun WANG
- Publication Type:Journal Article
- Keywords:
Polymyositis;
Dermatomyositis;
Lung disease,interstitial;
Meta-analysis;
Predictive factors
- From:
Chinese Journal of Rheumatology
2011;15(9):588-591
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo systematically review and evaluate the predictive factors of interstitial lung disease(ILD) in patients with polymyositis and dermatomyositis (PM/DM), and provide evidence for early clinical diagnosis. MethodsThe predictive factors of PM/DM-related ILD from 23 published papers were analyzed by Meta-analysis. Analysis of heterogeneity and sensitivity were performed and pooled odds ratio (OR) with 95％ confidence interval(95％CI) were calculated using either fixed or random effects models by Rev-Man 4.2 software. Stata 10.0 software was used to identify publication bias. ResultsMeta-analysis was performed to analyze seven factors including anti-Jo-1 antibody, fever, arthritis/arthralgia, Gottron's sign,antinuclear antibody(ANA), and dysphagia Raynaud's phenomenon. Factors correlated with ILD in patients with PM/DM and their OR values and 95％CI were as follows: the presence of anti-Jo-1 antibody 6.94 (4.74～10.16), fever 4.90(3.82～6.29), arthritis/arthralgia 3.93(3.21～4.80), Gottron's sign 2.52(1.24～5.14), and the presence of ANA 1.59( 1.02～2.47 ). Raynaud's phenomenon and dysphagia were not correlated with ILD in patients with PM/DM with OR values and 95％CI as 1.40 (0.97～2.01), and 1.21(0.94～1.56) respectively.ConclusionThe presence of anti-Jo-1 antibody, fever, arthritis/arthralgia, Gottron's sign and ANA are major predictive factors for ILD in patients with PM/DM.
