Relationship between the polymorphism of the AT2R gene 1675A/G and the effect of indapamide sustained release tablets in female hypertension patients
10.3760/cma.j.issn.1008-6315.2012.12.012
- VernacularTitle:AT2受体基因1675A/G多态性对吲达帕胺缓释片在女性降压中疗效研究
- Author:
Yuchuan DAI
;
Chuanfang LI
;
Lijun GAN
;
Meng ZHANG
;
Yuntao CHENG
;
Junxia GUO
- Publication Type:Journal Article
- Keywords:
Primary hypertension;
AT2R gene;
Indapamide sustained release tablets;
Polymorphism
- From:
Clinical Medicine of China
2012;28(12):1273-1276
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship of the1675A/G polymorphism of AT2 gene with the therapeutic effect of indapamide sustained release tablets in female patients with primary hypertension.Methods Two hundred and twenty female patients with primary hypertension were treated with Indapamide Sustained Release Tablets ( 1.5 mg · qd) for 8 weeks.The blood samples from the patients were collect to determine AT2 gene polymorphism by PCR combined with HRM and sequencing.Results Two hundred and five patients completed the test.In female patients,the therapeutic efficacy of indapamide sustained telease tablets among different AT2R genotypes( AA:70.6％,AG:71.6％,GG:71.4％ ) showed no significant difference ( x2=2.53,P=0.49 ),neither do the decline of BP after therapy ( F=0.39 and 0.19 respecrively,P ＞ 0.05).Conclusion The AT2 genotype was assumed to be not correlated to the blood pressure lowering response to Indapamide Sustained Release Tablets in female primary hypertension patients.
