Clinical significance of the serum fibrosis parameters in Chronic hepatitis B patients

VernacularTitle:慢性病毒性乙型肝炎患者血清肝纤维化指标检测的临床意义
Author: Zhixin ZHENG ; Chuangkun CHEN ; Chenggui XU
Publication Type:Journal Article
Keywords: Hepatitis B,Chronic; Liver cirrhosis; Collagen type Ⅳ; Hyaluronic acid; Laminin; Collagen type Ⅲ
From: Chinese Journal of Primary Medicine and Pharmacy 2012;19(21):3222-3223
CountryChina
Language:Chinese
Abstract: Objective To study the relationship between serum fibrosis parameters levels and chronic viral hepatitis B patients.Methods Radioimmunoassay and chemiluminescence were used to test the levels of hyaluronic acid(HA),collagen type Ⅳ(Ⅳ-C),laminin(LN) and procollagen type Ⅲ(PC Ⅲ) in 146 cases of chronic hepatitis B and 40 of normal controls,and the relationship with clinical parameters of liver function were analyzed.Results The levels of HA,Ⅳ-C,LN,PC Ⅲ in chronic hepatitis B patients were higher than those of normal control group (P ＜0.05 or P ＜ 0.01),there were statistical differen in different course of disease (P ＜ 0.05 or P ＜ 0.01) ; The levels of serum Ⅳ-C and PCⅢ had positive correlation with plasma PT,the same to HA with TBil and PCⅢ with ALT;The levels of HA,Ⅳ-C and LN had negative correlation with Alb,the same to LN with CHE.Conclusion The levels of HA,Ⅳ-C,LN and PC Ⅲ in chronic hepatitis B patients may reflect the situations of hepatic fibrosis and the degrees of liver function damage.