The climical value of serum progesterone and estradiol to the diagnosis of embryo arrest in early pregnancy patients
10.3760/cma.j.issn.1008-6706.2012.21.011
- VernacularTitle:妊娠早期胚胎停止发育患者血清孕酮及雌二醇水平检测的意义
- Author:
Xiaohong WANG
- Publication Type:Journal Article
- Keywords:
Embryonic development;
Embryo loss;
Early diagnosis;
Progesterone;
Estradiol
- From:
Chinese Journal of Primary Medicine and Pharmacy
2012;19(21):3220-3221
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the clinical relationship of progesterone(P) and estradiol(E2) for embryo arrest in early pregnant patients.Methods 118 patients with embryo arrest in early pregnancy were selected and divided into two groups,research group (58 cases,embryo arrest in early pregnancy) and control group (60 cases,threatened abortion but embryo keeping growth by tocolysis).Serum P and E2 were measured and compared between two groups.Receiver operating characteristic curves(ROC) of all indexes were drawn and the areas under the ROC curves were calculated to evaluate diagnostic value.Results Compared to control group,the serum P and E2 were lower in research group(P ＜ 0.05).To diagnosis embryo arrest,the threshold for P was less than 118.4nmol/L,with 93.9％ sensitivity and 87.3％ specificity; while the threshold value for E2 was less than 1110pmol/L,with 95.6％ sensitivity and 90.7％ specificity.Conclusion Detection of serum P and E2 may be helpful for the diagnosis of embryo arrest in early pregnancy,and the serum E2 had the best diagnostic value.
