The diagnostic value of serum angiopoietin-2 level for gastric cancer
10.3760/cma.j.issn.1008-6706.2012.21.010
- VernacularTitle:血管生成素-2检测对胃癌的诊断价值
- Author:
Hui ZHENG
- Publication Type:Journal Article
- Keywords:
Stomach neoplasms;
Angiopoietin-2;
Enzyme-linked immunosorbent assay;
Diagnosis,differential
- From:
Chinese Journal of Primary Medicine and Pharmacy
2012;19(21):3218-3219
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the diagnostic value of serum angiopoietin-2 (Ang-2) level for gastric cancer.Methods Serum Ang-2 level waa measured by enzyme-linked immunosorbent assays (ELISA) in samples from 108 patients with gastric cancer,50 patients with chronic gastritis and 50 normal controls.Results The serum Ang-2 level in patients with gastric cancer [(1539.0 ± 449.3) ng/L] was significantly higher than that in patients with gastritis [(1044.6 ± 246.1) ng/L,P ＜ 0.01] and normal control [(1075.6 ± 228.2) ng/L,P ＜ 0.01)].There was no significant difference of serum Ang-2 level between patients with gastritis and normal control.Gastric cancer patients with lymph node metastasis had significantly higher serum Ang-2 level than those without metastasis (P ＜0.01).The area under ROC curve of serum Ang-2 level for diagnosis of gastric cancer was 0.819.Conclusion The serum Ang-2 level will be a useful indicator for diagnosis of gastric cancer.
