Study of the plasma thrombomodulin and von Willebrand factor determination in the diagnosis and treatment of acute ischemic colitis
10.3760/cma.j.issn.1673-4904.2012.25.007
- VernacularTitle:血浆血栓调节蛋白和血管性血友病因子测定在急性缺血性结肠炎诊治中的研究
- Author:
Wei JIN
;
Hongmei ZHOU
;
Tao DONG
;
Yongzhu LI
;
Cunxin ZHAO
;
Yinhua ZHANG
- Publication Type:Journal Article
- Keywords:
Colitis,ischemic;
Thrombomodulin;
von Willebrand factor
- From:
Chinese Journal of Postgraduates of Medicine
2012;35(25):18-20
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo study the changes of the plasma thrombomodulin(TM) and von Willebrand factor (vWF) levels and their clinical significance associated with the extent and severity of acute ischemie colitis.MethodsThe plasma TM and vWF levels were determined by enzyme linked immunosorbent assay in 46 patients with acute ischemic colitis (acute ischemic colitis group),42 patients with ulcerative colitis (ulcerative colitis group) and 40 healthy subjects (control group).ResultsThe plasma TM was (49.6 ±2.3) μg/L,and vWF was(198.8 ±8.9)％ in acute ischemic colitis group.The plasma TM was (38.2 ± 3.8) μ g/L,and vWF was ( 162.6 ± 7.6)％ in ulcerative colitis group.The plasma TM was (23.8 ±2.3) μg/L,and vWF was ( 116.7 ± 6.2)％ in control group.The plasma TM and vWF levels in acute ischemic colitis group were higher than those in ulcerative colitis group and control group (P ＜ 0.05 or ＜ 0.01 ).The plasma TM and vWF levels in ulcerative colitis group were higher than those in control group (P＜ 0.05).The plasma TM levels[(49.9 ± 0.3 ) μg/L] and vWF [(210.6 ± 8.2 ) ％] in all colon disease were higher than those in partial colon disease (P ＜ 0.05 ).ConclusionThe changes of plasma TM and vWF levels can be used as one of the indicators for assessment of the development and the prognosis of acute ischemic colitis.
