Preliminary study of brain function regional homogeneity in transient ischemic attack

VernacularTitle:短暂性脑缺血发作间期脑功能局部一致性初步研究
Author: Lan PENG ; Dongbai LIU ; Dinghua LIU ; Jianyu ZHANG ; Shimin CAI ; Xianping MENG
Publication Type:Journal Article
Keywords: Ischemic attack,transient; Magnetic resonance imaging; Regional homogeneity
From: Chinese Journal of Postgraduates of Medicine 2012;35(25):7-9
CountryChina
Language:Chinese
Abstract: ObjectiveTo investigate the brain function in the patients with transient ischemic attack (TIA) using index of regional homogeneity ( ReHo ).MethodsSixteen TIA patients ( TIA group ) and 16 age-matched normal controls(control group) underwent standard resting state functional MRI (fMRI)scan.The changes of the brain ReHo were studied by DPARSF analysis.ResultsCompared with that of control group,TIA group showed significantly decreased ReHo in the left cingulate gyrus (z =-3.72),left frontal gyrus (z =-3.02),right frontal gyrus (z =-3.23),right superior frontal gyrus (z =-3.75),right precuneus (z =-3.80),right inferior parietal lobule (z =-3.98 ),left inferior parietal lobule (z =-3.82),precentral gyrus ( z =- 3.85 ),right midfrontal gyrus ( z =-4.15 ),right midtemporal gyrus (z =- 3.43 ),and increased ReHo in the right hippocampus (z =3.37) and right cerebellum (z =3.55).Conclusion The rest-state brain function is abnormal in TIA interictal phase,and the increased ReHo in the hippocampus and cerebellum may reflect stress-induced brain protection of TIA and partial comoensatory response.