Diagnostic value of serum tissue inhibitor of metalloproteinase in severe sepsis patients with disseminated intravascular coagulation
10.3760/cma.j.issn.1671-0282.2012.11.015
- VernacularTitle:脓毒症合并弥漫性血管内凝血患者血清金属蛋白酶组织抑制剂的水平及诊断价值
- Author:
Jingchun SONG
;
Dunzhong HU
;
Tao WANG
;
Zili CHEN
;
Zhaofen LIN
- Publication Type:Journal Article
- Keywords:
Severe sepsis;
Disseminated intravascular coagulation;
Tissue inhibitor of metalloproteinase
- From:
Chinese Journal of Emergency Medicine
2012;21(11):1242-1246
- CountryChina
- Language:Chinese
-
Abstract:
Objective To examine the levels of serum tissue inhibitor of metalloproteinase in severe sepsis patients with disseminated intra-vascular coagulation (DIC) and evaluate its diagnostic value in severe sepsis with DIC.Methods Sixty patients were divided into 3 groups,namely severe sepsis group (SS group,n =28),severe sepsis with DIC group (SSD group,n =12) and normal group (n =20).Clinical data including APACHE Ⅱ score and DIC score of these patients were collected.Serum levels of TIMP-1 and TIMP-2 of these patients were measured by using ELISA.Results The patients of SS group had higher levels of TIMP-1 (723.74 ± 96.27) and lower levels of TIMP-2 (68.08 ± 14.87) than healthy control subjects (TIMP-1:574.24 ± 79.99,TIMP-2:89.99 ± 18.45) (P ＜ 0.05).The patients of SSD group had higher levels of TIMP-1 (907.56 ± 200.20) and lower levels of TIMP-2 (44.84 ± 22.13) than patients of SS group (P ＜ 0.05).An association was found between TIMP-1 and fibrinogen (FIB) (r =-0.392,P ＜ 0.05),TIMP-1 and D-dimer (r =0.407,P ＜ 0.05),TIMP-2 and PLT (r =0.484,P ＜0.01),TIMP-2 and PCT (r=-0.523,P＜0.01),TIMP-2 and DIC score (r=-0.579,P＜0.01).The areas under the curves (AUC) for TIMP-1/TIMP-2 was 0.896 (95％ CI:0.843 ～ 0.950 (P ＜ 0.05).Conclusions Serum levels of TIMP-1 in patients with severe sepsis complicated with DIC increased and TIMP-2 decreased,suggesting they were valuable in diagnosis of severe sepsis complicated with DIC.
