The expression and significance of Caspase-3/Bax in TCM differentiation of syndromes typing for ulcerative colitis
10.3760/cma.j.issn.1673-4246.2012.11.006
- VernacularTitle:半胱天冬氨酸酶-3、相关X蛋白与溃疡性结肠炎辨证分型的相关性
- Author:
Qian WANG
;
Yonghui Lü
;
Limei ZHOU
;
Wenjian CHEN
;
Guiying JIANG
;
Yi JIANG
;
Tiaoji LIN
- Publication Type:Journal Article
- Keywords:
Caspase-3;
Bax;
ulcerative colitis;
dampness-heat internal accumulation syndrome group;
deficiency of spleen and stomach syndrome group
- From:
International Journal of Traditional Chinese Medicine
2012;34(11):979-981
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the correlation between TCM differentiation of syndromes typing for ulcerative colitis (UC) and expressions of Bax and Caspase-3.Methods 50 patients with UC were divided into 2 groups according to TCM syndrome differentiation including dampness-heat internal accumulation syndrome group (25cases),deficiency of spleen and stomach syndrome group (25cases).Immunohistochemistry was used to study expression of Bax and Caspase-3 in colonic mucosas and compare with the normal group (25cases).Results The expressions of Bax were highest in dampness-heat internal accumulation syndrome group (4.56±1.58).The expressions of Bax of deficiency of spleen and stomach syndrome group were lower than dampness-heat internal accumulation syndrome group(3.28± 1.14)scores.There were significant differences between the three groups (P＜0.05).However,There were no significant difference between dampness-heat internal accumulation syndrome group and deficiency of spleen and stomach syndrome group in terms of the Caspase-3expressions (P＞0.05).In addition,Caspase-3 and Bax were positively related in each group(r=0.23and 0.21).Conclusion The high expressions of Bax,Caspase-3 in ulcerative colitis were closely related to TCM typing according to syndrome differentiation.Caspase-3 and Bax were adjustment in apoptosis.The detection of expression of Bax,Caspase-3 is helpful to the TCM syndrome differentiation and to the selection of treatment plan.At the same time,it can provide more important experiment basses for the pathogenesis of ulcerative colitis.
