Relationship between human equilibrative nucleoside transporter 1 and gemcitabine chemoresistance in pancreatic cancer
10.3760/cma.j.issn.1673-4203.2012.10.017
- VernacularTitle:人平衡核苷转运体1与胰腺癌化疗耐药性的关系
- Author:
Jianchun XIAO
;
Taiping ZHANG
;
Yupei ZHAO
- Publication Type:Journal Article
- Keywords:
Human equilibrative nucleoside transporter 1;
Pancreatic neoplasms;
Drug therapy;
Drug resistemce
- From:
International Journal of Surgery
2012;39(10):698-701
- CountryChina
- Language:Chinese
-
Abstract:
Gemcitabine has become a first-line chemotherapeutic durg.Unfortunately,many patients fail to derive benefits from gemcitabine in clinics.The variability of human equilibrative nucleoside transporter 1 (hENT1)expression in tumor cells,which plays a dominant role in the transport of gemcitabine across the cell membrane,may be one of the reason for gemcitabine chemoresistance in pancreatic cancer.
