Research advances of SOX7 gene in breast cancer
10.3760/cma.j.issn.1673-4203.2012.10.016
- VernacularTitle:SOX7基因在乳腺癌中的研究进展
- Author:
Rongjun ZHANG
;
Jiaxin ZHANG
;
Deyuan FU
;
Haosheng TAN
;
Jing SHI
;
Wenxi SHAO
- Publication Type:Journal Article
- Keywords:
Breast neoplasms;
Genes;
SOX7;
β-catenin;
Cyclin D1
- From:
International Journal of Surgery
2012;39(10):695-698
- CountryChina
- Language:Chinese
-
Abstract:
Study found that in some human tumors such as breast cancer,SOX7 gene is highly likely to be a tumor suppressor gene.The tumor suppressor role of SOX7 may be accomplished by regulating the Wnt/β-catenin signaling pathway mediated the transcription process,and the abnormal Wnt/β-catenin signaling pathway is likely to play its role through the regulation of its downstream target gene Cyclin D1,etc,so that the ahnormal cell proliferation activity is unable to carry on,and thus plays the function of tumor suppressor.This review will summarize the research progress of the role of SOX7 geue and its closely related β-catenin,Cyclin D1 gene in breast cancer.
