Lysophosphatidic acid promotes hepatocellular carcinoma
10.3760/cma.j.issn.1673-4203.2012.10.015
- VernacularTitle:溶血性磷脂酸促进肝细胞癌发生的研究进展
- Author:
Yi CHEN
;
Xiaobo WANG
;
Jianping GONG
- Publication Type:Journal Article
- Keywords:
Carcinoma,hepatocellular;
Receptors,lysophosphatidic acid;
Neoplasm metastasis;
Cell proliferation
- From:
International Journal of Surgery
2012;39(10):692-694
- CountryChina
- Language:Chinese
-
Abstract:
Hepatocellular carcinoma is the fifth most common malignant cancer worldwide with a continuously increasing incidence annually,highly malignant degree and poor prognosis.There is few effective treatment for hepatocellular carcinoma at present,based on the principle of surgical resection and chemotherapy.The present study showed that lysophosphatidic acid is highly expressed in tumor tissue,bile and serum in the patient with hepatocellular carcinoma.It plays an important role in hepatocellular carcinoma migration,invasion and tumor growth.Therefore,the mechanism which lysophosphatidic promots hepatocellular carcinoma is reviened as fellow.
