Biliary flora in patients with obstructive jaundice due to pancreatic head cancer
10.3760/cma.j.issn.1673-4203.2012.10.010
- VernacularTitle:胰头癌伴恶性梗阻性黄疸患者胆汁细菌检出的临床分析
- Author:
Yong SHEN
;
Deliang FU
;
Chen JIN
;
Ji LI
;
Yang DI
;
Feng YANG
;
Sijie HAO
;
Yanling ZHANG
- Publication Type:Journal Article
- Keywords:
Pancreatic neoplasms;
Jaundice,obstructive;
Bile;
Bacteria
- From:
International Journal of Surgery
2012;39(10):676-680
- CountryChina
- Language:Chinese
-
Abstract:
Objective To survey the biliary flora in patients with obstructive jaundice due to pancreatic head cancer,also the multiple factors which affect the positive findings of bile culture in these patients.Methods The information of 65 patients with obstruetive jaundice due to pancreatic head eancer,who admitted to surgery in Huashan Hospital from Oetober 2007 to October 2008 were reviewed retrospectively.The factors which may potentially affect the detection of bile pathogen in patients with malignant obstructive jaundice were studied with univarite analysis and muhivariate analysis,including age,history of biliary surgery,yellow stained time,serum alanihe aminotransferase level,serum bilirubin level,CA19-9 level,tumor size,site of obstruction,with or without clinical manifestations of biliary infection,and APACHE Ⅱ score.Results Twenty-five positive cultures happened in 65 bile samples (38.5％),including 21 strains of Gram-negative baeilli (72.4％),6 strains of Gram-positive bacteria (20.7％),and 2 strains of fungi (6.9％).Univariate analysis showed that the relevant factors which may affect the rate of positive bile culture in patients with malignant obstructive jaundice were age,history of biliary surgery,biliary obstruction site,biliary tract infection symptoms and APACHE Ⅱ score.Multivariate analysis showed that age,history of biliary surgery,biliary obstruction site and APACHE Ⅱ seore were independent risk factors.Conctusion Age,history of biliary surgery,biliary obstruction site and APACHE Ⅱ score were independent risk factors which led to positive findings of bile cultures in patients with obstructive jaundice due to pancreatic head cancer.
