Protein expressions and clinical significance of β-catenin and glycogen synthase kinase 3 beta in the gastric carcinomas
10.3760/cma.j.issn.1008-1372.2012.09.010
- VernacularTitle:胃癌中β-catenin和GSK-3β的表达及临床意义
- Author:
Wei DU
;
Xiusheng HE
- Publication Type:Journal Article
- Keywords:
Stomach neoplasms/pathology;
Stomach neoplasms/metabolism;
Stomach neoplasms/enzymology;
Cadherins/biosynthesis;
Glycogen synthase kinase 3/biosynthesis
- From:
Journal of Chinese Physician
2012;14(9):1189-1192
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the expressions ofβ-catenin and glycogen synthase kinase 3 beta(GSK-3β) proteins in the gastric carcinomas and to elucidate their clinical significance.Methods The expressions of β-catenin and GSK3-β proteins were analyzed with immunohistochemistry staining of gastric tissue array in the normal gastric mucosa (n =48),paracancerous tissues ( n =24),and primary cancer tissues ( n =48).ResultsThe positive expression rate ofβ-catenin and GSK-3β in gastric carcinomas was 66.7％ and 35.4％,respectively,and β-catenin protein expression in carcinomas was higher than normal and paracancerous tissues ( x2 =65.455,P ＜ 0.05 ).The expression of β-catenin was correlated with cell differential degree,pTNM stage,histological type,lymph node memtastasis,and nerve invasion,respectively ( x2 =4.713,8.242,13.662,11.658,4.550,P ＜ 0.05 or P ＜ 0.01 ).The positive expression rate of GSK3βin carcinomas was lower than normal and paracancerous tissues ( x2 =26.968,P ＜ 0.05).The expression of GSK-3β was correlated with cell differential degree,histological type,and lymph node metastasis,respectively (x2 =3.868,9.665,9.872,P ＜ 0.05 or P ＜ 0.01 ).The expression of β-catenin was negatively correlated with the expression of GSK-3βprotein in the gastric carcinoma tissues ( r =-0.493,P =0.001 ).ConclusionsGSK3-β and β-catenin might play important roles in the progression,differentiation,infiltration,lymph node metastasis of gastric carcinoma,and might be the indicators for diagnosis of a gastric carcinoma.
