Application of tirofiban and thrombus-aspiration catheter in the percutaneous coronary intervention-treated patients with acute ST-segment elevation myocardial infarction
10.3760/cma.j.issn.1008-1372.2012.09.014
- VernacularTitle:血栓抽吸导管联合替罗非班在急性ST段抬高性心肌梗死介入治疗中的应用
- Author:
Guohua WANG
;
Hui LIU
;
Lili YUAN
;
Chunyuan WU
- Publication Type:Journal Article
- Keywords:
Tyrosine/analogs & derivatives/pharmacology;
Suction;
Myocardial infarction/therapy;
Angioplasty,transluminal,percutaneous coronary
- From:
Journal of Chinese Physician
2012;14(9):1205-1207
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo assess the effects and safety of glycoprotein Ⅱ b/Ⅲ a receptor inhibitors tirofiban( intracoronary administration and venous maintenance) combined with DIVERTM CE thrombus-aspiration catheter in the percutaneous coronary intervention (PCI)-treated patients with acute ST-segment elevation myocardial infarction (ST-EMI).Methods Sixty patients with ST-EMI who underwent PCI were randomized into two groups.Thirty-two patients in group A were treated with tirofiban,twenty-eight patients in group B were treated with tirofiban and thrombus-aspiration catheter.Between two groups,the thrombolysis in myocardial infarction (TIMI) risk score,hemorrhagic complications,and incidence of major adverse cardiovascular events (MACE) were compared.ResultsThe TIMI flow was improved in both groups,and it was better in group B than group A ( P ＜ 0.05 ).The incidence of MACE in group B was lower than group A (25.0％ vs 3.6％,P ＜0.05). No fatal hemorrhagic complications were found in both groups.ConclusionsApplication of tirofiban and DIVERTM CE thrombus-aspiration catheter is safe and effective in ST-EMI patients,which can greatly improve myocardial reperfusion and reduce incidence of MACE.
