Clinical characteristic of autoimmune pancreatitis: an analysis of 81 patients
10.3760/cma.j.issn.1674-1935.2012.05.002
- VernacularTitle:自身免疫性胰腺炎81例临床特征分析
- Author:
Lei XIN
;
Guolin PENG
;
Zhuan LIAO
;
Lianghao HU
;
Xuejiao CHANG
;
Minghua ZHU
;
Jianming ZHENG
;
Chunshu PAN
;
Qian SHEN
;
Zhaoshen LI
- Publication Type:Journal Article
- Keywords:
Pancreatitis,autoimmune;
Pancreatitis,chronic;
Disease attributes;
Immunoglobulin G4;
Lymphoplasmacytic sclerosing pancreatitis
- From:
Chinese Journal of Pancreatology
2012;12(5):294-298
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the clinical characteristic of Chinese autoimmune pancreatitis (AIP) patients.Methods All clinical data of 81 patients with a diagnosis of AIP in Shanghai Changhai Hospital from February 2005 to May 2012 were analyzed.Results The sex ratio was 7.1∶1 and the mean age was (57± 12) years old in 81 patients with AIP.Obstructive jaundice was the initial symptom in 51.9％ (42/81) patients.In patient receiving CT,focal and diffuse type accounted for 45 and 35 patients.respectively,and pseudocyst was the main manifestation in 1 patient,biliary tract was involved in 59(72.8％ ) patients,dilatation of main pancreatic duct was observed in 5 ( 11.1％ ) patients.In patients receiving PET-CT,diffuse increased Flourine-18 FDG uptake by the pancreas was found in 11 patients,focal increased uptake in 2patients,and significant extra-pancreatic uptake was found in 5 patients.The positive rate of serum IgG4,CA19-9,ss DNA,anti-nuclear antibody and ds-DNA antibody was 94.6％ (53/81),54.4％ (37/68),14.3％ (4/28),10.7％ (3/28),7.1％ (2/28),respectively.The pathological findings of H-E staining and IgG4 immunohistochemical analysis in 20 patients were consistent with lymphoplasmacytic sclerosing pancreatitis.Conclusions Type 1 AIP is the main subtype of AIP in China.Combining clinical symptoms,extra-pancreatic manifestations,imaging or nuclear medicine findings,serology,cytology or histology can effectively increase the correct diagnosis rate of AIP.
