Relationship between serum procalcitonin，high mobility group box chromoso(m)al protein 1 levels and severity and prognosis of acute pancreatitis
10.3760/cma.j.issn.1674-1935.2012.05.003
- VernacularTitle:降钙素原、高迁移率族蛋白1与急性胰腺炎严重程度和预后的相关性研究
- Author:
Weijie ZHANG
;
Guifang XU
;
Zhiqiang TIAN
;
Guozhong WU
;
Xiaoping ZOU
- Publication Type:Journal Article
- Keywords:
Pancreatitits;
Procalcitonin;
High mobility group proteins;
Prognosis
- From:
Chinese Journal of Pancreatology
2012;12(5):299-301
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the serum levels of procalcitomn (PCT) and high mobility group box chromosomal protein-1 ( HMGB1 ) in patients with acute pancreatitis (AP) ; and study the relationship between the serum levels of PCT,HMGB1 and the severity and prognosis of AP.Methods The blood samples were collected from 80 AP patients,including 38 severe acute pancreatitis (SAP) patients and 42 mild acute pancreatitis (MAP) patients.The serum levels of HMGB1 were measured by ELISA kit,and the levels of PCT were measured by immunoassay chemiluminescent technique,then their relationship with other biochemical parameters,the severity and prognosis of AP was analyzed.30 healthy adults were treated as the control group.Results The serum PCT and HMGB1 levels were ( 8.18 ± 3.24) μg/L and ( 11.79 ± 3.98 ) μg/L in SAP group,and the corresponding values were (5.67 ± 2.43) μg/L and ( 5.38 ± 2.06) μg/L in MAP group,and both were significantly higher than those in control group [ ( 1.85 ± 0.86) μg/L and ( 1.87 ± 1.47) μg/L,P ＜0.01 ].The serum level of PCT was positively correlated with serum 1evel of HMGB1 ( r =0.276,P =0.014),and both were positively correlated with Ranson score,APACHE Ⅱ score,Balthazar CT score (P＜0.05 or ＜0.01 ).The HMGB1 levels were significantly higher in patients with organ dysfunction than those in patients without organ dysfunction (P ＜0.05).Conclusions In AP patients,serum PCT and HMGB1 levels were significantly increased,and they were positively correlated with disease severity.These results suggest that PCT and HMGB1 may act as potential serum markers for AP severity evaluation.
