The expression of Twist in invasive ductal carcinoma of breast and its relationship with cell proliferation and angiogenesis
10.3760/cma.j.issn.1673-4904.2012.29.007
- VernacularTitle:乳腺浸润性导管癌中Twist的表达与细胞增殖和血管生成的关系
- Author:
Fenglin CAI
;
Chunlan HE
;
Jiaxin ZHANG
;
Shifu ZHOU
;
Weifeng SHI
- Publication Type:Journal Article
- Keywords:
Breast neoplasms;
Twist protein;
Ki-67 antigen;
Microvascular density
- From:
Chinese Journal of Postgraduates of Medicine
2012;35(29):17-19
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo study the expression of Twist in invasive ductal carcinoma of breast and its relationship with cell proliferation and angiogenesis.MethodsThe expression of Twist and Ki-67 was detected in 60 cases with invasive ductal carcinoma of breast by immunohistochemistry.Ki-67 index and microvascular density(MVD) were calculated.ResultsThe positive expression rate of Twist was 56.7％ (34/60) in invasive ductal carcinoma of breast.Ki-67 index and MVD in the patients with positive expression of Twist was higher than those in the patients with negative expression of Twist[(57.05 ± 16.37)％ vs.(25.32 ± 16.16)％,(34.30 ± 12.25)％ vs.(23.04 ± 10.45)％,P＜ 0.05 ].ConclusionsThe overexpression of Twist is found in invasive ductal carcinoma of breast.To stimulate cell proliferation and angiogenesis may be one of the pathways of Twist to contribute to the invasion and metastasis of breast cancer.
