Histone modification and neural stem cell differentiation

VernacularTitle:组蛋白修饰与神经干细胞分化
Author: Xiang ZHOU ; Yang WANG ; Zhifeng DENG
Publication Type:Journal Article
Keywords: Histones; Methylation; Neurons; Stem Cells; Cell Differentiation
From: International Journal of Cerebrovascular Diseases 2012;20(9):717-720
CountryChina
Language:Chinese
Abstract: Neural stem cell (NSC) has self-renewal and differentiation potential.It can orderly differentiate into neurons,astrocytes and oligodendrocytes in the development of central nervous system.NSC differentiation was commonly regulated by a variety of factors,including cytokines,transcription factors and epigenetic factors.Epigenetic regulation is a heritable gene expression without changing the DNA sequence.Histone modification is an important regulation mode in epigenetic modifications,which is essential in the transcription process.It also plays a critical role in the development of central nervous system.This article briefly reviews the histone methylation and demethylafion in the regulation of NSC differentiation.