Histone deacetylases regulate angiogenesis: a possible treatment strategy of improving stroke
10.3760/cma.j.issn.1673-4165.2012.08.014
- VernacularTitle:组蛋白去乙酰化酶调控血管发生:一种可能的改善卒中的治疗策略
- Author:
Juan LIU
;
Yang WANG
;
Zhifeng DENG
- Publication Type:Journal Article
- Keywords:
Histone Deacetylases;
Histone Deacetylase Inhibitors;
Neovascularization,Pathologic;
Vascular Endothelial Growth Factors;
Hypoxia-Inducible Factor 1;
Endothelial Cells;
Stroke;
Brain Ischemia
- From:
International Journal of Cerebrovascular Diseases
2012;20(8):627-630
- CountryChina
- Language:Chinese
-
Abstract:
Currently,the most effective treatment for acute ischemic stroke is administration of tissuetype plasminogen activator for intravenous or intra-arterial thrombolysis within 3 to 6 hours after symptoms onset.However,the narrow therapeutic time window and the risk of intracranial hemorrhage have limited its clinical application.Angiogcncsis refers to the process of the formation of new functional blood vessels with the manner of germination from the already existing network of blood vessels.An increasing number of studies have shown that histone deacetylases involve in the regulation of angiogenesis.It may become a potential stroke treatment strategy.This article reviews the role of histone deacetylases in the regulation of angiogenesis.
