Research progress of clinical xenotransplantation
10.3760/cma.j.issn.1673-4203.2012.09.017
- VernacularTitle:异种移植的研究进展
- Author:
Jinxin ZHANG
;
Xiao LI
;
Junjie LI
- Publication Type:Journal Article
- Keywords:
Transplantation,heterologous;
Pigs,transgenic;
Graft rejection;
Natural heteroantibody
- From:
International Journal of Surgery
2012;39(9):625-629
- CountryChina
- Language:Chinese
-
Abstract:
The shortage of organs and cells from the donors continues to restrict allotransplantation.To carry out the xenotransplantation of pig as the donor is a very important method to alleviate the problem.At present,the organs of pigs (such as islet cells,neurons,liver ceils and cornea) have been initially used in clinical practice.However,significant barriers to be overcome before pig organ xenotransplantation can become a clinical therapy because of the immune and physiological disorders.With pigs that express one or more human thromboregulatory or anti-inflammatory genes being developed,the research of the xenotransplantation has made significant progress,the survival time is logner,at the same time,risk of cross-infection between species is smaller.However,immune rejection and physiological obstacles still prevent organ xenotransplantation from clinical application.This review will draw attention to the latest progress of the xenotransplantation,and provide some references for researchers.
