Clinical significance of human telomerase RNA component and C-myc gene expression in cervical cancer and precancerous lesions

VernacularTitle:人类端粒酶RNA和C-myc基因在子宫颈癌及癌前病变组织中的表达及其临床意义
Author: Hanzhen XIONG ; Yuexin YANG ; Zhongtang XIONG ; Shaoyan LIU ; Qingping JIANG
Publication Type:Journal Article
Keywords: Uterine cervical neoplasms; Human telomerase RNA component; Genes,myc
From: Cancer Research and Clinic 2012;24(8):508-511
CountryChina
Language:Chinese
Abstract: Objective To investigate the expression level of human telomerase RNA component (hTERC) and C-myc in cervical lesions.Methods Fluorescence in situ hybridization (FISH) was applied to detect hTERC and C-myc expression in 62 cases of cervical tissue including 35 cases of cervical intraepithelial neoplasia,8 cases of invasive cervical cancer,19 cases of inflammation as controls.Results The positive rates of hTERC on chromosome 3 in chronic cervicitis organizations,CIN Ⅰ,CIN Ⅱ-Ⅲ and cervical cancer were 5.3 ％ (1/19),16.7 ％(2/12),87.0 ％ (20/23),87.5 ％ (7/8) (x2 =36.299,x2 =40.237,P ＜0.01).The positive rates of C-myc in chronic cervical inflammation organization,CIN Ⅰ,CIN Ⅱ-Ⅲ and cervical cancer were 5.3 ％ (1/19),8.3 ％ (1/12),78.3 ％ (18/23),62.5 ％ (5/8) (x2 =30.200,x2 =34.224,P ＜0.01 ).The differences among groups were statistically significant.hTERC had a positively correlation with C-myc expression (r =0.514,P ＜ 0.01).Conclusion The expression of hTERC and C-myc on chromosome 3 is closely related to cervical cancer progression.