Expression of Survivin and cyclooxygenase-2 and their relationship in cervical carcinoma

VernacularTitle:Survivin与环氧合酶2在子宫颈癌中的表达及二者相关性研究
Author: Jing HE ; Jieqiang LYU ; Xiaohong HOU
Publication Type:Journal Article
Keywords: Cyclooxygenase 2; Uterine cervical neoplasms; Apoptosis; Survivin
From: Cancer Research and Clinic 2012;24(8):518-520
CountryChina
Language:Chinese
Abstract: Objective To investigate the Survivin and Cyclooxygenase-2 (COX-2) expression and their relationship in cervical carcinoma tissues and to investigate the relationship with the genesis and devclopment of cervical carcinoma.Methods The expression of Survivin and COX-2 was assayed by immunohistochemical technique in 60 cervical carcinoma and 30 normal cervical tissue specimens.The relation with its clinical pathology characters were analysed.Results Survivin and COX-2 expression in the tissues of cervical carcinoma [76.7 ％ (46/60),63.3 ％ (38/60)] were higher than that in normal cervical tissues evidently [6.7 ％ (2/30),10.0 ％ (3/30)] (P ＜ 0.05).The COX-2 expression in cervical carcinoma was positively associated with lymph node metastasis (P ＜ 0.05),but no correlation was found between COX-2 expression and age,clinical stages,grades and invasive depth (P ＞ 0.05).Any correlation between Survivin expression and classical prognostic factors of cervical carcinoma was found.Moreover,these two proteins were positively correlated.Conclusion The Survivin and COX-2 might play important roles in the development of cervical carcinoma.