DNA image cytometry in breast fine needle aspiration cytology

VernacularTitle:全自动DNA图像分析在乳腺细针穿刺细胞学诊断中的应用
Author: Rui WANG ; Heng WANG ; Yun DU
Publication Type:Journal Article
Keywords: DNA; Image cytometry; Breast masses; Fine meedle aspiration cytology
From: Cancer Research and Clinic 2012;24(8):521-523
CountryChina
Language:Chinese
Abstract: Objective To discuss the diagnosis value of DNA imaging cytometry (DNA-ICM) analysis in fine needle aspiration cytology (FNAC).Methods Conventional cytopathology and DNA-ICM were used to detect 95 fine needle aspiration patients with breast masses.The results were analyzed according to the histopathological diagnosis.Results There was not significant difference between conventional cytopathology and DNA-ICM [88.4 ％(84/95) vs.94.7 ％(90/95)] (x2 =2.457,P =0.117).Two false positive cases had been found in conventional cytopathologic diagnosis,but not in DNA-ICM.There was a positive correlation between the nucleus area and its DNA content (r =0.744,P =0.000).By DNA-ICM,the detectable rate of abnormal DNA content in the infiltrating ductal carcinoma was higher than that in the infiltrating lobular carcinoma [90.3 ％(65/72) vs.50.0 ％(4/8)] (P =0.011).Conclusion The detection of DNA-ICM can reduce the false positive rate of FNAC,but it has limitations in diploid tumors.