Casticin inhibits proliferation and invasion of breast cancer MCF-7 cells
10.3760/cma.j.issn.1006-9801.2012.08.007
- VernacularTitle:紫花牡荆素抑制乳腺癌MCF-7细胞增殖与侵袭能力的研究
- Author:
Jihong HUANG
;
Shaoying CHEN
;
Jian ZHENG
- Publication Type:Journal Article
- Keywords:
Casticin;
Breast neoplasms;
Cell proliferation;
Neoplasm invasiveness
- From:
Cancer Research and Clinic
2012;24(8):524-526
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of casticin on proliferation and invasion on human breast cancer MCF-7 cells.Methods MTT assay and invasion assay were performed in MCF-7 cells treated with casticin,respectively.The expression of Bax,Caspase-3,MMP-2 and MMP-9 was analyzed by RT-PCR and Western blot.Results Casticin inhibited MCF-7 cells proliferation and invasion in a dose-dependent manner (P < 0.05).Additionally,Bax and Caspase-3 expression was increased in MCF-7 cells treated with casticin,whereas MMP-2 and MMP-9 were down-regulated.Conclusion Casticin may play a critical role in inhibiting breast tumor cell proliferation and invasion,reinforcing its potential in clinical application.