Clinical analysis of 3DCRT on brain stem glioma in 36 cases
10.3760/cma.j.issn.1006-9801.2012.08.012
- VernacularTitle:脑干胶质瘤三维适形放疗36例临床分析
- Author:
Haiwei JIA
;
Jun ZHANG
;
Jingbo KANG
;
Yunke XU
;
Xiaomei YAN
- Publication Type:Journal Article
- Keywords:
Brain stem;
Glioma;
Radiotherapy,computer-assisted
- From:
Cancer Research and Clinic
2012;24(8):540-543
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyse the survival time and related factors of patients with brain stem glioma who received 3DCRT.Methods Thirty-six patients with brain stem tumor were admitted from October 2004 to December 2008 and all received 3D-CRT with the dosage (50-54 Gy,25-30 f,5-6 weeks).During treatment,the patients’ outcomes were analyzed by observing the changes of symptoms,signs and adverse radiotherapy reaction and all of them were followed-up in the next 3 years.The survival data were analyzed by Kaplan-Meire method.Results The median survival time was 9 months in the 23 pediatric patients and 15 months in 13 adult patients.One-,two-and three-year survival rates between pediatric group and the adult group were 43.5 ％ (10/13) vs 76.9 ％ (10/13),26.1％ (6/23) vs 46.2 ％ (6/13),8.7 ％ (2/23) vs 38.5 ％ (5/13).Karnofsky performance scale score at admission (x2 =20.059,P =0.000),tumor site (x2 =17.585,P =0.000),growth pattern (x2 =21.247,P =0.000) were associate with survival time.Conclusion 3DCRT is an effective therapy to brain stem glioma,childhood onset,pontine glioma,diffusion style and Karnofsky performance scale less than 80 are risk factors of poor prognosis.
