Relationship between single nucleotide polymorphism of urokinase-type plasminogen activator gene and tongue carcinoma
10.3760/cma.j.issn.1006-9801.2012.08.013
- VernacularTitle:尿激酶型纤溶酶原激活剂基因单核苷酸多态性与舌癌的关系
- Author:
Xuecai YANG
;
Wei SHANG
;
Feng ZHONG
;
Muyun JIA
;
Lingxue BU
;
Ningyi LI
- Publication Type:Journal Article
- Keywords:
Tongue neoplasms;
Urinary plasminogen activator;
Polymorphism,single nucleotide
- From:
Cancer Research and Clinic
2012;24(8):544-546
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine association between tongue carcinoma and polymorphism of urokinase-type plasminogen activator (PLAU) gene.Methods PLAU genotypes of 97 patients with tongue carcinoma and 91 health controls were examined by the PCR-RFLP method.Statistical analyses included a chi-square test for homogeneity and logistic regression analysis.Results The polymorphism in PLAU gene was rs2227564 C/T.Logistic analyses indicated that compared with CT and TT genotypes,CC genotype was risk factor for development of tongue carcinoma (adjusted OR =1.281,95 ％ CI 1.098-2.577,P =0.037).Conclusion PLAU polymorphism may be associated with development of tongue carcinoma.
