Effect of mechanical loading on osteoclast apoptosis and its regulation mechanisms
10.3760/cma.j.issn.1673-4181.2012.04.011
- VernacularTitle:力学载荷对破骨细胞凋亡的影响及其调节机制
- Author:
Qingxin HAO
;
Xizheng ZHANG
- Publication Type:Journal Article
- Keywords:
Mechanical loading;
Osteoclast;
Apoptosis;
Regulation
- From:
International Journal of Biomedical Engineering
2012;35(4):234-237
- CountryChina
- Language:Chinese
-
Abstract:
Osteoclast is one of the basic function cells involved in bone metabolism during the process of bone remodeling.Osteoclasts are responsible for destruction and absorption of the old bone tissue.Thus,a tiny change of osteoclast apoptosis may change the process of bone remodeling.Osteoclast apoptosis is regulated by many factors including estrogen,bisphosphonates and so on.However,fewer researches on effect of mechanical loading on the biological activity of osteoclasts has been carried out.In this paper,the effect of mechanical loading on the biological activity of osteoclasts and its regulation on apoptosis of cells and osteoclast are reviewed.
