Clinical and neuroimagings analysis in 10 patients with lupus encephalopathy

VernacularTitle:狼疮脑病10例临床神经影像特征分析
Author: Zhi LIU ; Lin CHEN ; Liying CUI ; Min QIAN ; Xiaoguang LI
Publication Type:Journal Article
Keywords: Lupus erythematosus, systemic; Movement disorders; Chorea; Magnetic resonance imaging
From: Chinese Journal of Neurology 2012;45(9):664-668
CountryChina
Language:Chinese
Abstract: Objective To report specific clinico-radiological syndromes in neuropsychiatric systemic lupus erythematosus (NPSLE).Methods Ten patients with NPSLE in Peking Union Medical College Hospital from 2005 to 2011 were studied retrospectively with magnetic resonance imaging, computer tomography or positron emission tomography. Results Posterior reversible encephalopathy syndrome was diagnosed in 2 patients with radiological features,headache and tonic-clonic seizure;3 patients with bilateral diffuse leukoencephalopathy,cognitive disorder and acute confusional state; 1 Fahr' s disease patient,with cognitive disorder and psychiatric symptom,movement disorder; 2 Parkinsonism patients with tremor and cogwheel rigidity,and 2 chorea patients. Conclusions The emergence of diffuse brain calcinosis,leukoencephalopathy and edema may happen in lupus encephalopathy particularly.Autoantibody reaction and vascular disease may play an important role in movement disorder including Parkinsonism and chorea.