Progresses in study of microRNA and gastric cancer
10.3760/cma.j.issn.1006-9801.2011.12.025
- VernacularTitle:microRNA与胃癌的研究进展
- Author:
Yongping MU
- Publication Type:Journal Article
- Keywords:
MicroRNAs;
Stomach neoplasms;
Tumor markers,biological
- From:
Cancer Research and Clinic
2011;23(12):858-861
- CountryChina
- Language:Chinese
-
Abstract:
MicroRNAs(miRNAs) are a class of micro,endogenously-initiated non-coding RNAs that negatively regulate gene expression at the post-transcriptional level. miRNAs have ability to negatively regulate the expression of genes involved in cell differentiation,proliferation,apoptosis and tumorigenesis.miRNAs could act as potential oncogenes and tumor repressors. Recent findings have demonstrated that miRNAs play critical roles in human gastric cancer.In this article,we reviewed the recent research progresses about the role of miRNAs in tumorigenesis,invasion and metastasis of gastric cancer and highlight the most significant and latest findings of original researches on potential implications of miRNA as a new class of biomarkers and therapeutic target in gastric cancer.
